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肿瘤科医学论文-18F2FDG PET2CT标准摄取值与NSCLC临床病理因素的关系
［摘要］ 目的 探讨非小细胞肺癌（NSCLC)病人18氟脱氧葡萄糖（18F2FDG)PET2CT标准摄取值（SUV)与临床病理因素的关系。方法 对80例确诊为NSCLC的病人治疗前行18F2FDG PET2CT检查，测得SUV最大值（SUVmax)，分析 SUVmax与原发肿瘤大小、临床分期、病理学类型及细胞分化程度之间关系。结果 肿瘤直径>3 cm组和≤3 cm组的SUVmax差异有统计学意义（t=4.17,P<0.05),不同临床分期（Ⅰ期与Ⅲa期、Ⅲb～Ⅳ期)SUVmax差异有统计学意义(F=7.05，P<0.01)。SUVmax与原发肿瘤大小及临床分期呈正相关（r=0.658，P<0.01；r=0.286,P<0.05)。结论 18F2FDG PET2CT的SUV值随着肿瘤大小和病期的增加呈升高的趋势，而与细胞分化程度和病理学类型无关。
【关键词】 癌 非小细胞肺 18氟脱氧葡萄糖 临床分期 标准摄取值 正电子发射断层显像术 体层摄影术 X线计算机 CORRELATION BETWEEN STANDARD UPTAKE VALUE OF 18F2FDG PET2CT AND CLINICOPATHOLOGIC FACTORS OF NON2SMALL CELL LUNG CANCER QIN CHEN, MA XUE2ZHEN (Department of Oncology, The affiliated Hospital of Qingdao University Medical College, Qingdao 266021, China);
［ABSTRACT］ Objective To investigate the correlation between standard uptake value (SUV) of 18F2FDG PET2CT and clinical factors of non2small cell lung cancer (NSCLC). Methods Eighty patients with confirmed NSCLC underwent whole2body 18F2FDG PET2CT scan before treatment. The maximal SUV (SUVmax) was obtained and its association with primary tumor size, clinical staging, pathological type, and cell differentiation of NSCLC was analyzed. Results The differences of SUVmax were significant between tumor sizes of >3 cm and ≤3 cm (t=4.17,P<0.05), and among different clinical stages (stageⅠand stages Ⅲa and Ⅲb-Ⅳ) (F=7.05,P<0.01). SUVmax showed a positive correlation with the size of primary tumor and clinical staging (r=0.658,P<0.01;r=0.286,P<0.05). Conclusion The SUV of 18F2FDG PET2CT tends to rise with the increase of tumor size and stage, but it has nothing to do with cell differentiation and the type of pathology of NSCLC.
［KEY WORDS］ Carcinoma, non2small cell lung; 18flurodeoxyglucose; Clinical staging; Standard uptake value; Positron2emission tomography; Tomography, X2ray computed
