ҽѧÂÛÎÄ·¶ÎÄ:ÊÓÇ°ÇøÏÂÇðÄÔÇ°²¿ÎÂÃôÉñ¾­ÔªµçÉúÀíÌØÐÔµÄÀë×ÓͨµÀ»úÖÆ

¡¾²Î¿¼ÎÄÏס¿

[1] Griffin JD.Central thermosensitivity and the integrative responses of hypothalamic neurons[J].J Therm Biol,2004,29:327ª²331.

[2] Griffin JD,Saper CB,Boulant JA.Synaptic and morphological characteristics of temperatureª²sensitive and ª²insensitive rat hypothalamic neurones[J].J Physiol,2001,537:521ª²535.

[3] Wagner EJ,Reyesª²Vazquez C,Ronnekleiv OK,et al.The role of intrinsic and agonistª²activated conductances in determining the firing patterns of preoptic area neurons in the guinea pig[J].Brain Res,2000,879(1ª²2):29ª²41.

[4] Robinson RB,Siegelbaum SA.Hyperpolarizationª²activated cation currents:from molecules to physiological function[J].Annu Rev Physiol,2003,65:453ª²480.

[5] Monteggia LM,Eisch AJ,Tang MD,et al.Cloning and localization of the hyperpolarizationª²activated cyclic nucleotideª²gated channel family in rat brain[J].Brain Res Mol Brain Res,2000,81(1ª²2):129ª²139.

[6] Santoro B,Chen S,Luthi A,et al.Molecular and functional heterogeneity of hyperpolarizationª²activated pacemaker channels in the mouse CNS[J].J Neurosci,2000,20(14):5264ª²5275Ò½.ѧ.È«.ÔÚ.Ïßwww.med126.com.

[7] Han J,Gnatenco C,Sladek CD,et al.Background and tandemª²pore potassium channels in magnocellular neurosecretory cells of the rat supraoptic nucleus[J].J Physiol,2003,546:625ª²639.

[8] Kang D,Choe C,Kim D.Thermosensitivity of the twoª²pore domain K+ channels TREKª²2 and TRAAK[J].J Physiol,2005,564:103ª²116.

[9] Patel AJ,Honore E.Properties and modulation of mammalian 2P domain K+ channels[J].Trends Neurosci,2001,24(6):339ª²346.

[10] Wechselberger M,Wright CL,Bishop GA,et al.Ionic channels and conductanceª²based models for hypothalamic neuronal thermosensitivity[J].Am J Physiol Regul Integr Comp Physiol,2006,291(3):R518ª²529.

[11] Unger NT,Kaple ML,Bishop GA,et al.Role of hyperpolarizationª²activated currents in hypothalamic neuronal thermosensitivity[J].The FASEB Journal,2007,21:923ª²929.

[12] Wright CL,Burgoon PW,Bishop GA,et al.Cyclic GMP alters the firing rate and thermosensitivity of hypothalamic neurons[J].Am J Physiol Regul Integr Comp Physiol,2008,294(5):1704ª²1715.

[13] Zhao Y,Boulant JA.Temperature effects on neuronal membrane potentials and inward currents in rat hypothalamic tissue slices[J].J Physiol,2005,564:245ª²257.

[14] Ranels HJ,Griffin JD.Effects of prostaglandin E2 on the electrical properties of thermally classified neurons in the ventromedial preoptic area of the rat hypothalamus[J].BMC Neurosci,2005,6:14.

[15] Guler AD,Lee H,Iida T,et al.Heatª²evoked activation of the ion channel,TRPV4[J].J Neurosci,2002,22(15):6408ª²6414.

[16] Benham CD,Gunthorpe MJ,Davis JB.TRPV channels as temperature sensors[J].Cell Calcium,2003,33(5ª²6):479ª²487.

[17] Kobayashi S,Hori A,Matsumura K,et al.Point:Heatª²induced membrane depolarization of hypothalamic neurons:a putative mechanism of central thermosensitivity[J].Am J Physiol Regul Integr Comp Physiol,2006,290(5):1479ª²1480.

[18] Unger NT,Kaple ML,Boulant JA.TRPV blockade by ruthenium red does not suppress thermosensitivity in hypothalamic neurons[J].The FASEB Journal,2008,22:956.15.

[19] Sharifª²Naeini R,Ciura S,Bourque CW.TRPV1 gene required for thermosensory transduction and anticipatory secretion from vasopressin neurons during hyperthermia[J].Neuron,2008,58(2):179ª²185.

[20] Tabarean IV,Conti B,Behrens M,et al.Electrophysiological properties and thermosensitivity of mouse preoptic and anterior hypothalamic neurons in culture[J].Neuroscience,2005,135(2):433ª²449.

[21] Boulant JA.Counterpoint:Heatª²induced membrane depolarization of hypothalamic neurons:an unlikely mechanism of central thermosensitivity[J].Am J Physiol Regul Integr Comp Physiol,2006,290(5):1481ª²1484.

[22] Reid G,Flonta M.Cold transduction by inhibition of a background potassium conductance in rat primary sensory neurones[J].Neurosci Lett,2001,297(3):171ª²174.

[23] McKemy DD,Neuhausser WM,Julius D.Identification of a cold receptor reveals a general role for TRP channels in thermosensation[J].Nature,2002,416(6876):52ª²58.

[24] Simon E.Ion channel proteins in neuronal temperature transduction:from inferences to testable theories of deepª²body thermosensitivity[J].Am J Physiol Regul Integr Comp Physiol,2006,291(3):515ª²517.

ÉÏÒ»Ò³  [1] [2] [3] [4] [5]  ÏÂÒ»Ò³